Vinnie Iyer is back for another season of fantasy football lineup advice, bringing his rankings and insights across all positions to help you make those tough Week 18 start 'em, sit 'em decisions based on matchups,

Lakes quarterback Jadis Lefono (10) raises his arms as Lakes running back Toetu Moliga-Taiepisi (22) lands in the end zone under a pile of Capital defenders for a touchdown on Friday, Oct. 24, 2025, in Lakewood, Wash. Liesbeth Powers lpowers@thenewstribune.com

If you're looking to fill a roster spot for your title-game matchup, here are a dozen possible pickups who could be difference-makers.

It all comes down to Week 18 in the NFC West and though the division title will come down to the Seahawks vs. 49ers matchup Saturday, the Rams aren't to be forgotten despite their Monday Night Football loss.

The NFC West and the top overall seed in the conference is on the line Saturday at Levi’s Stadium when the San Francisco 49ers (12-4) host the Seattle Seahawks (13-3). Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season.