Week 18 is upon us in the NFL, and the conclusion of the 2025 regular season has many playoff scenarios, including the remaining two spots in the AFC and NFC.

Mike Florio and Chris Simms dive into the Seattle Seahawks vs. San Francisco 49ers matchup that will decide the winner of the NFC West as well as the conference's No. 1 seed.

Week 18 can bring a wide variety of games, from must-win scenarios (Carolina Panthers at Tampa Bay Buccaneers and Baltimore Ravens at Pittsburgh Steelers) to games key for playoff seeding to games that will only impact the draft order.

The NFL playoff picture isn't totally set in stone, but you could sketch out a good deal of it in permanent marker.

Week 17 of the 2025 NFL regular season is here. The 17th week of the 2025 NFL regular season is a big one for several reasons. It's the second to last week of the regular season, with playoff berths needing to be locked up and playoff positions needing to be secured.